The original GAinS study, which has now closed, recruited a total of 2404 patients with community acquired pneumonia or faecal peritonitis, making this one of the largest bio-repositories of sepsis cases in the world.

Funded by an MRC Research Grant of more than £900,000 GAinS2/sepsis immunomics has started to recruit all cause sepsis patients to a multi-omic study of the host response to sepsis, which includes ward based cases and convalescent samples, as well as patients admitted to intensive care. The overall objective of this study is to further our understanding of the host/immune response in sepsis to inform a precision medicine approach to management. Although currently recruitment is confined to Oxford we plan to expand to include additional sites in the coming months.


After almost two long years of remote working, researchers from the Knight Group (The University of Oxford), the Davenport Group (The University of Cambridge) and London Universities gathered in person to discuss the recent advances in sepsis research as part of the Genomic Advances in Sepsis study. Key highlights included a talk on the development of SepstratifieR, a new computational approach for assigning SRS endotype cross-platform by Eddie Cano Gamez. Yuxin Mi also gave an excellent talk updating on the large proteomic study (~2000 individuals) which hopes to identify novel biomarkers of disease.

The full schedule can be found here: