Chief Investigators:
Professor (Emeritus) and Consultant in Intensive Care Medicine
Intensive Care Unit, Barts and the London Queen Mary School of Medicine and Dentistry, London
Professor of Genomic Medicine and Honorary Consultant Physician
Principal Investigator, Wellcome Centre for Human Genetics, University of Oxford
Co-investigators:
Group Leader at the Wellcome Sanger Institute.
Chair in Anaesthesia and Critical Care at Imperial College and Consultant in Intensive Care Medicine based at St Mary’s Hospital
Prof. Julian Bion (Intensive Care Unit, Queen Elizabeth University Hospital, Birmingham)
Dr Stuart McKechnie, Consultant in Intensive Care and Anaesthetics, Oxford University Hospitals NHS Trust
Prof Adrian Hill (Wellcome Centre for Human Genetics, Oxford)
Dr Kenneth Baillie, Academic Consultant in Critical Care Medicine at the University of Edinburgh and Edinburgh Royal Infirmary
Prof. Mark Caulfield (Director, Genome Centre, Barts and The London Queen Mary’s School of Medicine and Dentistry, London)
Dr Paul A Holloway (Division of Investigative Science, Imperial College, London)
Dr Charles Mein (Genome Centre, Barts and The London Queen Mary’s School of Medicine and Dentistry)
Research nurse and study coordinator:
Paula Hutton
Senior research nurse and GAinS study coordinator.
Paula is based at the Adult Intensive Care Unit at the John Radcliffe Hospital in Oxford.
Researchers:
Postdoctoral Fellow in the Davenport group at the Wellcome Sanger Institute
Katie recently completed her PhD looking at inter-individual variation in the host sepsis response using a functional genomics approach.
MRC/BJA Clinical Research Training Fellow in Julian Knight’s group at the Wellcome Centre for Human Genetics, Oxford
Cyndi is a clinician in Intensive Care Medicine and is currently in the final year of her PhD using next-generation sequencing techniques to more accurately classify sepsis aetiology.
Academic Clinical Lecturer based at the Big Data Institute in the University of Oxford
Alex is a clinician specialising in Infectious Disease Medicine and uses modern scientific technologies to identify patients with severe infections early, aiming to improve outcomes in these devastating diseases.
Second year PhD student studying functional genomics of sepsis in Julian Knight’s group at the Wellcome Centre for Human Genetics, Oxford.
Yuxin is working on characterisation of the sepsis proteome for identifying novel disease endotypes and potential biomarkers.
Dr Andrew Kwok
Second year PhD student in genomics in Julian Knight’s group at the Wellcome Centre for Human Genetics, Oxford.
Andrew completed his clinical training in 2017 and is now looking to study the genomics and immunology of sepsis to better understand the pathophysiology of the condition
First year PhD student in Genomic Medicine and Statistics, co-supervised by Julian Knight and Rachael Bashford-Rogers at the Wellcome Centre for Human Genetics, Oxford.
Lauren’s PhD will focus on understanding the adaptive immune response to sepsis through sequencing of the B-cell and T-cell receptor repertoires.
First year PhD student in Medical Genomics, supervised by Emma Davenport at the Wellcome Sanger Institute, Cambridge.
Alex is investigating the role of alternative splicing in the sepsis response, and the relationship of different pathogens with this diversity.
UK Critical Care Genomics 