L. Pereverzeva et al., Blood leukocyte transcriptomes in gram-positive and gram-negative community-acquired pneumonia. European Respiratory Journal, 2101856 (2021).
Goh, C., et al., Epstein-Barr virus reactivation in sepsis due to community-acquired pneumonia is associated with increased morbidity and an immunosuppressed host transcriptomic endotype. Sci Rep, 2020. 10(1): p. 9838.
Antcliffe, Burnham et al. Transcriptomic signatures in sepsis and a differential response to steroids: from the VANISH randomized trial. American Journal of Respiratory and Critical Care Medicine 2019; 199 (8): 980-986
Tridente et al. Methodological challenges in European ethics approvals for a genetic epidemiology study in critically ill patients: the GenOSept experience. BMC Med Ethics 2019; 20 (1):30.
Torrance et al. Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery. Plos ONE 2018; 13(9): e0203795
Sweeney et al. A community approach to mortality prediction in sepsis via gene expression analysis. Nature Communications 2018; 9 (1):694
Lashin et al. Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis. Shock 2018; 49 (4):393-401
Annane et al. Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis. Annals of Intensive Care 2018; 8 (1):16
Scicluna et al. Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respiratory Medicine 2017; 5 (10):816-826
Tridente et al. Derivation and validation of a prognostic model for post-operative risk stratification of critically ill patients with faecal peritonitis. Annals of Intensive Care 2017 7:96
Burnham et al. Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia. American Journal of Respiratory and Critical Care Medicine 2017; 196:328-339
Goh and Knight Enhanced understanding of the host-pathogen interaction in sepsis: new opportunities for omic approaches. Lancet Respiratory Medicine 2017; 5 (3):212-223
Davenport et al. Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respiratory Medicine 2016; 4 (4):259-71
Scherag et al. Genetic factors of the disease course after sepsis: A genome-wide study for 28 day mortality. EBioMedicine 2016; 12:239-246
Mills et al. Variants in the mannose-binding lectin gene MBL2 do not associate with sepsis susceptibility or survival in a large European cohort. Clinical Infectious Diseases 2015; 61 (5): 695-703
Owen et al. Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma. Journal of Trauma and Acute Care Surgery 2015; 79: 766-772
Torrance et al. Changes in gene expression following trauma are related to the age of transfused packed red blood cells. Journal of Trauma and Acute Care Surgery 2015; 78: 535-542
Longbottom et al. Features of postoperative immune suppression are reversible with interferon gamma and independent of interleukin-6 pathways. Annals of Surgery 2016; 264 (2): 370-377
Tridente et al. Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort. Critical Care 2015; 19 (1): 210
Rautanen et al. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respiratory Medicine 2015; 3:53-60
Torrance et al. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Annals of Surgery 2015; 261 (4):751-9
Fragkou et al. Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study. Critical Care 2014; 18 (5):541
Walden et al. Patients with community acquired pneumonia admitted to European Intensive Care Units: an epidemiological survey of the GenOSept cohort. Critical Care 2014; 18 (2):R58
Dalli et al. Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Molecular Medicine 2014; 6 (1):27-42
Tridente et al. Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort. Intensive Care Medicine 2014; 40 (2):202-10
Mills et al. IFITM3 and susceptibility to respiratory viral infections in the community. Journal of Infectious Diseases 2014; 209 (7):1028-31
Dalli et al. Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. Molecular and Cellular Proteomics 2013; 12 (8):2205-19
Gordon, Knight, Hinds (Editorial) Genes and sepsis: How tight is the fit? Critical Care Medicine 2008; 36 (5):1652-4
Eisen et al. Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clinical Infectious Diseases 2008; 47 (4):510-6
Garrard, Hinds, Knight. Applications in critical care medicine. In: Kumar D, Weatherell D (eds) Genomics and Clinical Medicine 2007, Oxford University Press
Gordon et al. Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 2006; 25 (1):88-93
Gordon et al. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes and Immunity 2004; 5 (8):631-40
UK Critical Care Genomics 